Modeling frequency-dependent action potential failures in CA3 pyramidal cell axons
نویسندگان
چکیده
منابع مشابه
Action potential initiation and propagation in CA3 pyramidal axons.
Thin, unmyelinated axons densely populate the mammalian hippocampus and cortex. However, the location and dynamics of spike initiation in thin axons remain unclear. We investigated basic properties of spike initiation and propagation in CA3 neurons of juvenile rat hippocampus. Sodium channel alpha subunit distribution and local applications of tetrodotoxin demonstrate that the site of first thr...
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The membrane potential changes following action potentials in thin unmyelinated cortical axons with en passant boutons may be important for synaptic release and conduction abilities of such axons. In the lack of intra-axonal recording techniques we have used extracellular excitability testing as an indirect measure of the after-potentials. We recorded from individual CA3 soma in hippocampal sli...
متن کاملCritical role of axonal A-type K+ channels and axonal geometry in the gating of action potential propagation along CA3 pyramidal cell axons: a simulation study.
A model of CA3 pyramidal cell axons was used to study a new mode of gating of action potential (AP) propagation along the axon that depends on the activation of A-type K+ current (Debanne et al., 1997). The axonal membrane contained voltage-dependent Na+ channels, K+ channels, and A-type K+ channels. The density of axonal A-channels was first determined so that (1) at the resting membrane poten...
متن کاملDeterminants of action potential propagation in cerebellar Purkinje cell axons.
Axons have traditionally been viewed as highly faithful transmitters of action potentials. Recently, however, experimental evidence has accumulated to support the idea that under some circumstances axonal propagation may fail. Cerebellar Purkinje neurons fire highfrequency simple spikes, as well as bursts of spikes in response to climbing fiber activation (the "complex spike"). Here we have vis...
متن کاملModeling with dependent failures
My broad research interest is in dependable systems, in particular developing fault-tolerant distributed algorithms and applying them to practical problems. Developing dependable systems is an important goal as we increasingly rely upon large-scale wide-area distributed systems to support a wide range of online services. As systems scale in size and extent, efficiently coping with failures is a...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2012
ISSN: 1471-2202
DOI: 10.1186/1471-2202-13-s1-p115